The attraction between two adjacent non-polar molecules increases in proportion to the area of contact. Generally, the closeness of the tie between the two increases with greater area of van der Waal’s contact attraction and also with the degree of hydrogen bonding. The higher the level of molecular fit, the stronger is the affinity between a molecule and the biomolecular target in therapeutic agents.A therapeutic agent or medicine in aqueous solution is stablized by hydrogen bonding to water and dipolar solvation. It is evident that in medicines, there is a trade-off; they must be sufficiently well solvated to be soluble in water, “but not so strongly solvated that they cannot be pulled from solution by the target biomolecule” (Corey et al 2012, p. Noncyclic organic molecules are usually flexible because the barrier to rotation about single bonds having low energy. Therefore, most medicines’ structures have cyclic subunits with a few preferred conformations, sometimes just one. show the conformation of prednisone, a significant anti-inflammatory and immunosuppressive drug, along with the preferred conformation of glucose.While the molecular formula for glucose is C5H12O6, the formula for prednisone is C21H26O5. “The polycyclic framework of prednisone is quite rigid and gives the molecule a characteristic shape” (Corey et al 2012, p. Concurrently, several polar functional groups are situated at specific sites in space, facilitating their optimal binding to the target molecule.There are compounds with a divalent central atom. According to the theory of Valence shell electron pair repulsion (VSEPR), two electron pairs belonging to a divalent central atom will be separated to the maximum width when the bond angle is 180 degrees. This means the molecule will have a linear structure. For example, Beryllium chloride BdCl2 with a divalent central atom is a linear molecule. Some compounds such as carbon dioxide CO2 and allene H2C=C=CH2 are also linear, similar to having a divalent central atom (Iwanami 2006).For compounds with a trivalent central atom such as boron trichloride BCl3, when the Valence shell electron pair repulsion (VSEPR) theory is applied, the bond angle
Corey, E.J., Czako, B. & Kurti, L., 2012. Molecules and medicine. The United Kingdom:
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