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Ulcerative colitis Essay Example

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Ulcerative colitis

Decreased oxidation of short chain fatty acids, increased intestinal permeability, an increase in the production of sulfides, and decreased methylation,’ (Head, and Jurenka, 2003). Certain cytokines along with anti-oxidant levels as well as the presence of bacteria interfere with normal system functions. These systematic functional abnormalities each contribute to symptoms of ulcerative colitis. For example increased oxidative stress is manifested in the intestinal mucosa of patients. Bowel lesions are much more evident when the bacteria concentration is highest, likely contributing to bloody stools and abdominal pains.Conventional treatments include antibiotics, corticosteroids, amino salicylates, and immune modulators. Corticosteroids are most often used during acute phases. Preventative measures to avoid flare ups during times of remission usually involve behavioral changes. It is commonly advised that nutrient deficits be checked for and corrected as UC is associated with several. Vitamin A, vitamin E, vitamin C, vitamin K, folic acid, calcium, iron, zinc, selenium and magnesium are all important elements are any deficiencies should be balanced though many if not all of these factor in any disease that has immune system implications as a causative factor. Special diets depending on chemistry results can be prescribed for prevention along with in some cases the use or probiotics in the diet. Specific nutrients are also thought to play roles in prevention.Major areas of ongoing research in ulcerative colitis involve genetics factors and genetic markers that are predictive of the disease. Protein tyrosine phosphatase non-receptor type 2 identified as a genome increasing susceptibility for UC (Brand, 2012). Despite this knowledge its phenotypic effects are unclear and being researched. Phenotypic effects are those effects that are observable due to the presence of this genome.One Korean study concluded that there was no association between the genomes TNFSF15 and IL23R in a Korean research group. This genome has been mentioned in reports and research findings among Caucasians though findings and conclusions have been inconsistent. Though the TNFSF15 genome for some reason shows a small association with UC it is in Caucasian male patients only (Kyuyoung, 2011).A third research study identified that UC shares many susceptibility genes with Crohn’s disease, which is good cause for further study as they are both irritable bowel syndromes and

References

Board, A. E., & National Center for Biotechnology Information. (2012, January 18). Ulcerative colitis Inflammatory bowel disease - ulcerative colitis; IBD - ulcerative colitis. Ulcerative Colitis. Retrieved October 14, 2012, from http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001296/

Head, Kathleen A., and Julie S. Jurenka. "Inflammatory Bowel Disease Part I: Ulcerative Colitis -- Pathophysiology And Conventional And Alternative Treatment Options." Alternative Medicine Review 8.3 (2003): 247-283. Academic Search Premier. Web. 14 Oct. 2012. Available at http://ehis.ebscohost.com/eds/pdfviewer/pdfviewer?vid=14&hid=1&sid=3ccd2417-ee90-4c3d-b332-69a1ecee0108%40sessionmgr114

Jack Satsangi, et al. "New Genes in Inflammatory Bowel Disease: Lessons For Complex Diseases." Lancet 367.9518 (2006): 1271-1284. Academic Search Premier. Web. 14 Oct. 2012. Available at http://ehis.ebscohost.com/eds/pdfviewer/pdfviewer?vid=5&hid=117&sid=3ccd2417-ee90-4c3d-b332-69a1ecee0108%40sessionmgr114

Kyuyoung Song, et al. "No Association Between TNFSF15 And IL23R With Ulcerative Colitis In Koreans." Journal Of Human Genetics 56.3 (2011): 200-204. Academic Search Premier. Web. 14 Oct. 2012. Available at http://ehis.ebscohost.com/eds/pdfviewer/pdfviewer?sid=3ccd2417-ee90-4c3d-b332-69a1ecee0108%40sessionmgr114&vid=14&hid=115

Leonid Padyukov, et al. "Genome-Wide Association Identifies Multiple Ulcerative Colitis Susceptibility Loci." Nature Genetics 42.4 (2010): 332-337. Academic Search Premier. Web. 14 Oct. 2012. Available at http://ehis.ebscohost.com/eds/pdfviewer/pdfviewer?sid=3ccd2417-ee90-4c3d-b332-69a1ecee0108%40sessionmgr114&vid=12&hid=115

Nikolaos Argyros, et al. "Ulcerative Colitis In The Elderly: Clinical Patterns And Outcome In 51 Greek Patients." Journal Of Gastroenterology 36.5 (2001): 312. Academic Search Premier. Web. 14 Oct. 2012. Available at http://ehis.ebscohost.com/eds/pdfviewer/pdfviewer?vid=10&hid=22&sid=3ccd2417-ee90-4c3d-b332-69a1ecee0108%40sessionmgr114

Sephton, M. "Nursing Management Of Patients With Severe Ulcerative Colitis." Nursing Standard 24.15-17 (2009): 48-58. CINAHL Plus with Full Text. Web. 14 Oct. 2012. Available at http://ehis.ebscohost.com/eds/pdfviewer/pdfviewer?vid=4&hid=5&sid=3ccd2417-ee90-4c3d-b332-69a1ecee0108%40sessionmgr114

Stephan Brand, et al. "PTPN2 Gene Variants Are Associated With Susceptibility To Both Crohns Disease And Ulcerative Colitis Supporting A Common Genetic Disease Background." Plos ONE 7.3 (2012): 1-10. Academic Search Premier. Web. 14 Oct. 2012. Available at http://ehis.ebscohost.com/eds/pdfviewer/pdfviewer?vid=8&hid=115&sid=3ccd2417-ee90-4c3d-b332-69a1ecee0108%40sessionmgr114

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preview essay on Ulcerative colitis
  • Pages: 4 (1000 words)
  • Document Type: Essay
  • Subject: Biology
  • Level: Ph.D.
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