Brooks, 2006. Bioscavengers-human serum butyrylcholinesterase (Hu BChE)-“sequesters highly toxic organophosphates before they reach their physiological targets”(Saxena et al. Galantamine-acts both as a “reversible competitive inhibitor of acetylcholinesterase (AChE) and as an allosteric modulator of nicotinic acetylcholine receptors” (Zarotsky, Sramek, Cutler, 2003. Pyridostigmine bromide-reversibly inhibits AChE and BuChE (Albuquerque et al., 2006) and therefore, allows normal transmission of nerve impulses across the neuromuscular junction. (Daily Med, 2007. Atropine toxicity- agitation, confusion, urinary retention, hyperthermia, bowel ileus, and tachycardia (Eddleston et al. Glycopyrrolate-tachycardia, dry mouth, and ileus. Oximes-dizziness, drowsiness, headache, tachycardia, blurred vision, diplopia, impaired accommodation, nausea, muscular weakness, hyperventilation, and pain at injection site. Diazepam-respiratory depression (Eddleston, Singh, Buckley, 2007). Galantamine-Nausea, vomiting, diarrhea, and dizziness. Less frequently it causes anorexia, headache, weight loss, and depression (Zarotsky, Sramek, Cutler, 2003). Pyridostigmine bromide-nausea, vomiting, diarrhea, abdominal cramps, increased peristalsis, increased salivation, increased bronchial secretions, miosis, and diaphoresis, muscle cramps, fasciculation and weakness. Organophosphate Poisoning and Treatment with Atropine.
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