Many organisms have membranes which are able to adapt to different climatic condition including the freezing temperature. The process in which the membrane adapts to cold temperature is referred to as cold acclimation processes. Through the process of cold acclimation and use of membrane proteome the organisms freezing tolerance is determined. The process of cold acclimation involves change of lipids and protein found in the membrane. The microdomain is a sub-domain for membrane made of proteins and lipids. Microdomain proteome provides an insight for the functions and changes that takes place during the process of cold acclimation. The proteins associated with cold acclimation are accumulated and found at microdomain fractions. Those proteins involved in cold acclimation include aquaporins, P-type ATPases and tubulins. During cold acclimation, the dynamin and clathrins related proteins are more concentrated in the microdomain (Ziegler and Kramer 2014).The membrane plays crucial role in cellular homeostasis and perception of signal like freezing temperature. The proteins contained in the membrane serve as an important feature in determining the ability of an organism or cell to tolerate freezing condition. Some animals are not able to survive in freezing environment. Membrane Transport and Extreme cold tolerance.
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