The development has enabled the use of TE in colon cancer. How is it being used? Researchers have taken advantage of TE to develop the colon through the transfer of organoid units on scaffolds made up of a polymer19. The organoid units, multicellular units obtained from neonatal rat ileum, were transferred into Lewis’s rat omentum20. Thus, through the adaptation of the tissue-engineered organoid technique, researchers opine that they can produce a colon that is TE produced. In short, tissue-engineered colon (TEC) has been synthesized and developed.
Scenarios do exist where total colectomy is required. Thus, the creation of a colostomy bag is necessary. Hence, if a patient can donate autologous cells, tissue engineered colon from the syngeneic tissue is possible21. Thus, researchers have been able to produce colons from an engineered tissue and adult cells with 100% results22. The tissue-engineered colon showed an architecture similar to the original colon. The TEC’smuscularispropria stained for actin, had ganglion cells, and S100-positive cells.23 In anastomosis, the colon architecture was preserved24. The produced colon has been shown to have constant in vitro function just like that in mature colonocytes25. Thus, if a colon has been damaged by colon cancer, TEC could be used as an effective means to replace the impaired colon.
Under esophageal tissue engineering, studies note that acellular scaffolds can be transplanted with the goal of having the smooth muscle and epithelial cells move to populate the conduit in use once more26. These scaffolds include the collagen scaffolds that have been utilized to create porous tube-like structures27. However, their use presented limitations due to a lack of regrowth in the muscles27. Synthetic scaffolds have been utilized but have poor results in terms of the migration of the cells caused by the features of the materials28. Decellularised scaffolds emanating from the esophagus shown to produce mixed results29.
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