Instead, it developed by chance. Individuals without the mutation residing in places that are endemic for malaria remained at a higher risk of contracting the malaria parasite followed by the development of this given infectious disease. Symptoms like enlarged spleens and high fevers were common among the affected individuals. Besides, it was observed that carriers of HGB. AS had higher chances of survival whenever malaria struck in comparison with the Hgb. AA carriers who always died during their first year of life if infected with malaria. Although the exact mechanism of how Sickle cell allele(S) impairs the development of Malaria is not yet fully known, it is widely believed that the infection of sickle cell trait red blood cells by P. falciparum often deform them in a way that they are marked as abnormal by macrophages before they are subsequently removed from the circulation and destroyed in the spleen together with the parasite (Ferreira 342). Other studies have suggested that the conditions in sickle cell trait erythrocytes may directly kill the Malaria parasites thereby impairing their proliferation. For example, some ultrastructural studies have revealed that incubating P. falciparum parasites at low oxygen tension similar to that of the sickle trait erythrocytes may cause extensive metabolic damage to the parasites. Sickle Cell Anemia - Symptoms and Causes.
Ferreira A, Marguti I. Sickle hemoglobin confers tolerance to Plasmodium infection. Cell 145.2 (2011):398-409. Print.
Hiren, Dhanani. “Sickle Cell Disease: History and Origin.” The Internet Journal of Haematology 1.2(2004): 23-28. Print.
Luzzatto, Lucio. Sickle Cell Anaemia and Malaria. Mediterr J Hematol Infect Dis. 4.1. (2012): 43-54. Print.
Malowany, Butany J. “Pathology of Sickle Cell Disease.” Diagnostic Pathology 29.1(2012):49-55.
Tapper, Melbourne. In The Blood: Sickle Cell Anemia and the Politics of Race. University of Pennsylvania Press, 2009.Print.
Thompson, Paul. The Structure of Biological Theories. New York: State University of New York Press, 1989. Print.
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